Two sample MR report
HLA-DQA2_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 68 | 0.0035722 | 0.0084487 | 0.6738030 |
| Weighted median | 68 | 0.0125996 | 0.0019064 | 0.0000000 |
| Inverse variance weighted | 68 | 0.0100571 | 0.0014504 | 0.0000000 |
| Simple mode | 68 | 0.0143807 | 0.0036423 | 0.0001915 |
| Weighted mode | 68 | 0.0140765 | 0.0039198 | 0.0006224 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 84.10923 | 66 | 0.0657368 |
| Inverse variance weighted | 84.88296 | 67 | 0.0691769 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0083068 | 0.0106607 | 0.4386524 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0023645 | 1e-07 | TRUE | 4e-06 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
